Modern pharmaceutical applications of Eudragit polymers in Hot Melt Extrusion and 3D printing technologies

Document Type : Research Paper

Author

Department of Pharmaceutics, College of Pharmacy, University of Mosul, Mosul, Iraq.

10.22103/jab.2025.25732.1747

Abstract

Objective
The pharmaceutical production environment is increasingly adopting progressive methods like hot-melt extrusion (HME) and three-dimensional (3D) printing to expand personalized, effective, and scalable drug delivery systems. Both techniques rely heavily on the excipient Eudragit (EUD), which represents a broad family of methacrylate-based polymers. This review targets to supply a wide account of the application of EUD polymers in HME and 3D printing, with a centralization on their role in controlled drug release systems of sustained, immediate, and aimed types.
Materials and Methods
The review surveys the utilization of numerous grades of EUD, like EPO, RL, RS, L100, S100, and L100-55, in formulation design, process optimization, and drug release mechanisms. The discussion encompasses the evaluation of formulation strategies, processing situations, and post-processing stability. Innovations in recent years, containing smart and functionalized EUD-based systems with mucoadhesive, colon-specific, and theranostic properties, are also examined. Additionally, mechanical characteristics and drug–polymer compatibility are analyzed as critical determinants of successful formulation.
Results
EUD polymers have been demonstrated to support a broad spectrum of drug delivery platforms and dosage forms, proposing versatility and adaptability to pharmaceutical processing. Case studies and recent expansions show the capability of EUD to enable controlled release mechanisms, while also addressing particular therapeutic requirements. Smart functionalization of EUD systems has expanded their potential to include mucoadhesion, site-specific delivery, and diagnostic utilizations. However, challenges stay, containing issues of thermal degradation through processing, insufficient miscibility between drugs and polymers, and sensitivity to moisture. These limitations pose meaningful formulation challenges that must be managed carefully via process-specific and formulation-specific solutions.
Conclusions
This review underscores the central role of EUD polymers in next-generation pharmaceutical manufacturing, exclusively in the context of HME and additive manufacturing. While these polymers hold great promise for enabling progressive drug delivery systems, technical challenges persist, containing drug–polymer miscibility, risk of thermal degradation, and maintenance of post-processing integrity. Addressing these issues is crucial for unlocking the full potential of EUD polymers in future drug expansion. By integrating case studies, formulation strategies, and mechanistic perception, this review supplies a worth resource for researchers and formulators seeking to exploit the adaptability of EUD in modern pharmaceutical utilizations.

Keywords

References

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Agricultural Biotechnology Journal
Volume 17, Issue 3
August 2025
Pages 345-384

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